Sequence, shape, and function. Synthetic Biology by DNA.
Inspired by the rich functionalities of natural macromolecular assemblies such as enzymes, molecular motors, and viruses, we seek means for building artifical nanodevices that can execute user-defined tasks. Molecular self-assembly with DNA* is an attractive route to achieve this goal and allows for building nanodevices that open new paths to scientific discovery in biomolecular physics and protein science**.
(*) A primer to DNA origami.;
(**) More about our research goals.
T Gerling, KF Wagenbauer, A Neuner, H Dietz: 'Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components' SCIENCE 2015
JP Sobczak, TG Martin, T Gerling, and H Dietz: 'Rapid folding of DNA into nanoscale shapes at constant temperature' SCIENCE 2012
M Langecker, V Arnaut, TG Martin, J List, S Renner, M Mayer, H Dietz, and F Simmel: 'Synthetic lipid membrane channels formed by designed DNA nanostructures' SCIENCE 2012
H Dietz, SM Douglas, and WM Shih: 'Folding DNA into twisted and curved nanoscale shapes.' SCIENCE 2009
SM Douglas, H Dietz, T Liedl, B Hogberg, F Graf, and WM Shih: 'Self-assembly of DNA into nanoscale three-dimensional shapes.' NATURE 2009